Background. Obesity is a major health concern and increases risk of metabolic syndrome, type 2 diabetes, dyslipidemia, cardiovascular diseases and many cancers. Obesity occurs with decreased physical activity and increased caloric intake. Clinical management is still limited. Brown adipose tissue is a thermogenic organ which expresses uncoupling protein 1. When activated it increases energy expenditure by up to 20%. Recent evidence suggests that white adipose tissue can be "browned" and have similar characteristics, called beige fat. Aim. To test a "beiging" agent capsaicin to determine whether it could brown human fat and improve metabolism. Methods. We used a "Humanised Mouse Model" where human fat is inserted intra-abdominally in immune suppressed mice (to avoid rejection). Mice were fed ad libitum normal or a high fat diet (45% calories from fat)±0.03% capsaicin. Metabolic studies were conducted before and after fat transplant and 12 weeks on diets. These studies included glucose and insulin...

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