A composition for lysing Staphylococcus aureus or a composition for preventing or treating a disease caused by Staphylococcus aureus, said composition comprising, as active ingredients, at least one bacteriophage selected from the group consisting of a bacteriophage identified under accession number NITE BP-693 and a bacteriophage identified under accession number NITE BP-694, and an endolysin that is at least one protein selected from the group consisting of (a) a protein having the amino acid sequence represented by SEQ ID NO: 1, (b) a protein that has an amino acid sequence having at least 80% identity to the amino acid sequence represented by SEQ ID NO: 1, and (c) a protein that has an amino acid sequence with the substitution, deletion, addition and/or insertion of one or more amino acids in the amino acid sequence represented by SEQ ID NO: 1.

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