An application of NADH and a salt thereof in the preparation of drugs or health food for preventing and treating pharyngitis. NADH and a pharmaceutically acceptable salt thereof can be used for preparing drugs or health food for preventing and treating pharyngitis. NADH or a salt thereof is used as the only active ingredient, there are various modes of administration to facilitate use, and the administration route and dosage can be determined according to the severity of the disease, so that inflammatory symptoms are significantly improved, basically no side effects are caused, and the recurrence rate is reduced.

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