Problem to be solved. To provide formulations containing an active ingredient that is based on natural products and has high safety, can be taken as food, and has high stability, the formulations having excellent anemia-improving action or anemia-preventing action without strengthening nutritional components (taking high protein and iron), and further characterized by that they may have at least one of the excellent effects according to the following (1) to (4): (1) Maintenance/increasing action of human red blood cell count; (2) maintenance/increasing action of hematocrit level in human blood; (3) maintenance/increasing action of hemoglobin concentration in human blood; and (4) maintenance/increasing action of the amount of albumin in human blood. Solution. A nucleic acid is used as an active ingredient of an anemia improving agent and/or an anemia preventing agent.

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